Fly half Simon Humberstone makes his first ever start for the region after impressing off the bench last week and joins forces with Alex Walker at half back. Centre Gavin Evans also returns in midfield.
Prop Sam Hobbs is called up at loosehead to captain the side while flanker Ellis Jenkins and Number Eight Robin Copeland are also named in the pack.
Blues are currently without 20 players for the game with Josh Navidi, Andries Pretorius, Marc Breeze, Ben Roach, Harry Robinson, Rhys Patchell, Gareth Davies among those ruled out.
Cardiff Blues: 15 Dan Fish, 14 Richard Smith, 13 Gavin Evans, 12 Dafydd Hewitt, 11 Chris Czekaj, 10 Simon Humberstone, 9 Alex Walker; 1 Sam Hobbs (c), 2 Kristian Dacey, 3 Benoit Bourrust, 4 Macauley Cook, 5 James Down, 6 Ellis Jenkins, 7 Thomas Young, 8 Robin Copeland.
Replacements: 16 Rhys Williams, 17 Taufa'ao Filise, 18 Tom Davies, 19 Miles Normandale, 20 Rory Watts-Jones, 21 Luke Hamilton, 22 Lewis Jones, 23 Tom Williams