Winger Alex Cuthbert scored a memorable try for Wales to cap an exceptional individual performance - but he was left helpless as South Africa snatched second Test glory in the most dramatic fashion.
Blues stars Cuthbert, Gethin Jenkins and Josh Turnbull all started an exhilarating game in Nelspruit while hooker Matthew Rees was a second half replacement.
Tries from former Blues ace Jamie Roberts and Cuthbert put dominant Wales in early control before a penalty try and Cornal Hendricks allowed the Springboks back into the game.
Ken Owens's try extended the lead but Willie Le Roux's effort and a last minute converted penalty try gave the Boks victory.
Meanwhile, there was also a disappointing defeat for new signing Manoa Vosawai as Italy's poor run of form continued against Japan.
Italy's three-Test series in June has failed to produce an upturn in fortunes, with a 25-14 reverse against Fiji followed by a disappointing 15-0 defeat at the hands of Samoa. And the losing streak has now been extended to nine games after a 26-23 defeat in Tokyo.
However, one Blue to taste victory in international rugby over the weekend was lock Filo Paulo who started the game as Samoa defeated Fiji 18-13 in the Pacific Nations Cup clash at the ANZ Stadium in Suva.
The result means both sides finish on six points in the Pacific Conference table of Pacific Nations Cup 2014. Samoa finishes top due to the fact that it beat Fiji and drew with Tonga, Fiji's six points coming from its bonus point win against Tonga and a bonus point for the narrow loss to Samoa.
Following recent communication with our loyal supporters, regarding changes to our Family Season Membership for the 2017-18 season, Cardiff Blues have decided to honour the existing pricing structure for current members.
Cardiff Blues travel to Myreside on Friday to take on Edinburgh Rugby in a crucial Guinness PRO12 clash, and with Wales facing Scotland in the RBS 6 Nations at BT Murrayfield on Saturday, it promises to be a weekend of non-stop rugby action at the Scottish capital. Here are some useful advice to Cardiff Blues travelling supporters.