Winger Alex Cuthbert scored a memorable try for Wales to cap an exceptional individual performance - but he was left helpless as South Africa snatched second Test glory in the most dramatic fashion.
Blues stars Cuthbert, Gethin Jenkins and Josh Turnbull all started an exhilarating game in Nelspruit while hooker Matthew Rees was a second half replacement.
Tries from former Blues ace Jamie Roberts and Cuthbert put dominant Wales in early control before a penalty try and Cornal Hendricks allowed the Springboks back into the game.
Ken Owens's try extended the lead but Willie Le Roux's effort and a last minute converted penalty try gave the Boks victory.
Meanwhile, there was also a disappointing defeat for new signing Manoa Vosawai as Italy's poor run of form continued against Japan.
Italy's three-Test series in June has failed to produce an upturn in fortunes, with a 25-14 reverse against Fiji followed by a disappointing 15-0 defeat at the hands of Samoa. And the losing streak has now been extended to nine games after a 26-23 defeat in Tokyo.
However, one Blue to taste victory in international rugby over the weekend was lock Filo Paulo who started the game as Samoa defeated Fiji 18-13 in the Pacific Nations Cup clash at the ANZ Stadium in Suva.
The result means both sides finish on six points in the Pacific Conference table of Pacific Nations Cup 2014. Samoa finishes top due to the fact that it beat Fiji and drew with Tonga, Fiji's six points coming from its bonus point win against Tonga and a bonus point for the narrow loss to Samoa.
Thank Blues it's Friday! The weekend will be starting HERE on Friday night as Cardiff Blues tackle Ulster in the Guinness PRO12 at BT Sport Cardiff Arms Park - and we want you to be our guest at our big match day party!
Let the Games Begin! Cardiff Blues launch the Guinness PRO12 season on home soil this Sunday afternoon against Glasgow Warriors (kick-off 4pm) - and we are going to make it a double celebration as we also recognise the achievements of Team Wales!
First team aces Cory Allen, Lloyd Williams, Ellis Jenkins and new signing Jarrad Hoeata were all on hand to watch the next generation of stars when Cardiff Blues held a huge Under-8s Tag Rugby tournament at BT Sport Cardiff Arms Park.
Second half tries from Dan Tuohy and Ian Humphreys saw Ulster claim the Friday night points on offer as Cardiff Blues suffered a 26-9 defeat to the impressive Irish province at BT Sport Cardiff Arms Park.
Clinical Glasgow Warriors produced a devastating final 20 minutes to secure the points on Super Sunday and consign battling Cardiff Blues to a 33-12 defeat in the Guinness PRO12 opener at BT Sport Cardiff Arms Park.
Impressive Cardiff Blues pushed English powerhouse side Leicester Tigers all the way with an hugely encouraging performance as final preparations for the new Guinness PRO12 season continued at Welford Road.