Winger Alex Cuthbert scored a memorable try for Wales to cap an exceptional individual performance - but he was left helpless as South Africa snatched second Test glory in the most dramatic fashion.
Blues stars Cuthbert, Gethin Jenkins and Josh Turnbull all started an exhilarating game in Nelspruit while hooker Matthew Rees was a second half replacement.
Tries from former Blues ace Jamie Roberts and Cuthbert put dominant Wales in early control before a penalty try and Cornal Hendricks allowed the Springboks back into the game.
Ken Owens's try extended the lead but Willie Le Roux's effort and a last minute converted penalty try gave the Boks victory.
Meanwhile, there was also a disappointing defeat for new signing Manoa Vosawai as Italy's poor run of form continued against Japan.
Italy's three-Test series in June has failed to produce an upturn in fortunes, with a 25-14 reverse against Fiji followed by a disappointing 15-0 defeat at the hands of Samoa. And the losing streak has now been extended to nine games after a 26-23 defeat in Tokyo.
However, one Blue to taste victory in international rugby over the weekend was lock Filo Paulo who started the game as Samoa defeated Fiji 18-13 in the Pacific Nations Cup clash at the ANZ Stadium in Suva.
The result means both sides finish on six points in the Pacific Conference table of Pacific Nations Cup 2014. Samoa finishes top due to the fact that it beat Fiji and drew with Tonga, Fiji's six points coming from its bonus point win against Tonga and a bonus point for the narrow loss to Samoa.
Cardiff Blues launch the new Guinness PRO12 season next Sunday when we entertain Zebre Rugby at BT Sport Cardiff Arms Park - and to celebrate the big kick-off we are offering a special ticket offer with Kids for a Quid for this fixture!
Rugby World Cup 2015 continues to grip the nation with over half a million local and international fans enjoying the Official Fanzones up and down the country to watch live matches and enjoy the excitement of the Tournament.
Cardiff Blues Rugby Camps will be back next month giving children right across our region the opportunity to participate in rugby during the holidays - and you can book NOW to avoid any disappointment!
Can't get tickets for the Rugby World Cup? Well now you won't have to miss a second of the action alongside passionate fans as we are running two special events so you can watch the big games with Cardiff Blues and in the company of some Welsh rugby legends!
Prop Sam Hobbs scored a dramatic injury time try - for the second successive season in Galway - as battling Cardiff Blues deservedly took home two bonus points from a pulsating Guinness PRO12 fixture with Connacht at The Sportsground.
New-look Cardiff Blues and Newport Gwent Dragons served up an entertaining pre-season encounter as the visitors edged to victory as the countdown to the new Guinness PRO12 season continued at BT Sport Cardiff Arms Park.