Cardiff Blues stars Alex Cuthbert, Cory Allen, Matthew Rees and Josh Turnbull will all represent Wales in their opening game in South Africa against Eastern Province Kings in Port Elizabeth on Tuesday (kick-off 7pm local time).
Warren Gatland's starting XV includes four uncapped players, with Matthew Morgan lining up at full-back, Steven Shingler at inside centre and Jordan Williams on the wing.
They are joined in the backline by Cardiff Blues duo Alex Cuthbert and Cory Allen as well as James Hook and Rhodri Williams at half back.
In the pack Paul James is named alongside Scott Baldwin and Rhodri Jones in the front-row with Jake Ball and Ian Evans in the second-row.
Captain Dan Lydiate is joined by new Cardiff Blues back row Josh Turnbull at flanker with Dan Baker at No 8.
On the bench Cardiff Blues hooker Matthew Rees is named in a Wales squad for the first time since February 2013.
Uncapped Gareth Davies is named amongst the replacements along with George North and Liam Williams.
WALES TEAM TO PLAY EASTERN PROVINCE KINGS:
Matthew Morgan (Ospreys), Alex Cuthbert (Cardiff Blues), Cory Allen (Cardiff Blues), Steven Shingler (Scarlets), Jordan Williams (Scarlets), James Hook (Perpignan), Rhodri Williams (Scarlets), Paul James (Bath), Scott Baldwin (Ospreys), Rhodri Jones (Scarlets), Jake Ball (Scarlets), Ian Evans (Ospreys), Dan Lydiate (Capt) (Racing Metro), Josh Turnbull (Cardiff Blues), Dan Baker (Ospreys).
Replacements: Matthew Rees (Cardiff Blues), Aaron Jarvis (Ospreys), Samson Lee (Scarlets), Luke Charteris (Perpignan), Aaron Shingler (Scarlets), Gareth Davies (Scarlets), George North (Northampton Saints), Liam Williams (Scarlets).
Thank Blues it's Friday! The weekend will be starting HERE on Friday night as Cardiff Blues tackle Ulster in the Guinness PRO12 at BT Sport Cardiff Arms Park - and we want you to be our guest at our big match day party!
Let the Games Begin! Cardiff Blues launch the Guinness PRO12 season on home soil this Sunday afternoon against Glasgow Warriors (kick-off 4pm) - and we are going to make it a double celebration as we also recognise the achievements of Team Wales!
As well as the half marathon on Sunday (October 5), the 2014 Lloyds Bank Cardiff Half Marathon also sees the return of the action-packed Lloyds Bank Festival of Running to Cardiff's Civic Centre on Saturday (October 4, starting 11am) where you can see our mascot Bruiser the Bear in action!
Second half tries from Dan Tuohy and Ian Humphreys saw Ulster claim the Friday night points on offer as Cardiff Blues suffered a 26-9 defeat to the impressive Irish province at BT Sport Cardiff Arms Park.
Clinical Glasgow Warriors produced a devastating final 20 minutes to secure the points on Super Sunday and consign battling Cardiff Blues to a 33-12 defeat in the Guinness PRO12 opener at BT Sport Cardiff Arms Park.