Cardiff Blues stars Alex Cuthbert, Cory Allen, Matthew Rees and Josh Turnbull will all represent Wales in their opening game in South Africa against Eastern Province Kings in Port Elizabeth on Tuesday (kick-off 7pm local time).
Warren Gatland's starting XV includes four uncapped players, with Matthew Morgan lining up at full-back, Steven Shingler at inside centre and Jordan Williams on the wing.
They are joined in the backline by Cardiff Blues duo Alex Cuthbert and Cory Allen as well as James Hook and Rhodri Williams at half back.
In the pack Paul James is named alongside Scott Baldwin and Rhodri Jones in the front-row with Jake Ball and Ian Evans in the second-row.
Captain Dan Lydiate is joined by new Cardiff Blues back row Josh Turnbull at flanker with Dan Baker at No 8.
On the bench Cardiff Blues hooker Matthew Rees is named in a Wales squad for the first time since February 2013.
Uncapped Gareth Davies is named amongst the replacements along with George North and Liam Williams.
WALES TEAM TO PLAY EASTERN PROVINCE KINGS:
Matthew Morgan (Ospreys), Alex Cuthbert (Cardiff Blues), Cory Allen (Cardiff Blues), Steven Shingler (Scarlets), Jordan Williams (Scarlets), James Hook (Perpignan), Rhodri Williams (Scarlets), Paul James (Bath), Scott Baldwin (Ospreys), Rhodri Jones (Scarlets), Jake Ball (Scarlets), Ian Evans (Ospreys), Dan Lydiate (Capt) (Racing Metro), Josh Turnbull (Cardiff Blues), Dan Baker (Ospreys).
Replacements: Matthew Rees (Cardiff Blues), Aaron Jarvis (Ospreys), Samson Lee (Scarlets), Luke Charteris (Perpignan), Aaron Shingler (Scarlets), Gareth Davies (Scarlets), George North (Northampton Saints), Liam Williams (Scarlets).
Cardiff Blues face Newport Gwent Dragons in a huge European Rugby Challenge Cup quarter-final on Saturday, April 4 - and you can celebrate pre and post-match with Cardiff Blues and the Cardiff Blues Supporters' Club at BT Sport Cardiff Arms Park!
Welsh Pro Rugby's main sponsor BT Sport will help make it a Welsh derby day to remember for thousands of rugby supporters at the big European quarter-final with the creation of a buzzing Family Village at Rodney Parade.
Cardiff Blues are hosting a special Open Evening this Wednesday night at BT Sport Cardiff Arms Park to give prospective students and parents the chance to discover more about our new and exciting rugby education programme.
Our Cardiff Blues Rugby Camps return this Easter to give children right across our region the opportunity to participate in rugby during the holidays - and after selling out our last two camps you can book NOW to avoid any disappointment!
Supporters are being invited to get on their bike and gear up for an epic charity bike ride from Cardiff to Paris this June - with the last few places now available to raise vital funds for #StayStrongForOws
The players at Cardiff Blues will be hoping to play with some true Gallic flair for the rest of the Guinness PRO12 season - after the region teamed up with a successful French bistrot in the Welsh capital.
Cardiff Blues will be celebrating St David's Day when the region faces Edinburgh Rugby at BT Sport Cardiff Arms Park on Sunday afternoon (kick-off 12.45pm) - with hundreds of children invited as part of our Regional Schools Day.
Fine footwear retailer The Brogue Trader - one of the official sponsors of Cardiff Blues - is celebrating after being recognised by the British Footwear Association at its annual Footwear Industry Awards.
Battling Cardiff Blues produced a second half performance packed full of character and spirit to push Ulster Rugby all the way in an absorbing Guinness PRO12 encounter at a packed out Kingspan Stadium.
Argentine ace Joaquin Tuculet scored a sensational try in the eighth minute of injury time as Cardiff Blues produced an astonishing finale to snatch victory over Connacht Rugby after an unbelievable Guinness PRO12 encounter.