Gareth Williams and Ben Evans both earn starting positions in the front row, and Maama Molitika teams up with Xavier Rush and Martyn Williams in the back row.
Ryan Powell and Martin Jones are named as replacements and also amongst the substitutes is Australian summer signing, Marc Stcherbina.
Rhys Williams (C), Chris Czekaj, Jamie Robinson, Tristan Davies, Craig Morgan, Nicky Robinson, Michael Phillips,
Xavier Rush, Martyn Williams, Mamma Molitika, Robert Sidoli, Deiniol Jones, Ben Evans, Gareth Williams, John Yapp
Martin Jones, Ross Johnson, Kort Schubert, Robin Sowden-Taylor, Ryan Powell, Marc Stcherbina, Lee Thomas
The game will be shown on S4C. Supporters travelling should note the new venue - for more information visit www.rds.ie/.
Supporters not travelling are invited to watch the game in the clubhouse with other fellow supporters - all welcome.