Craig Morgan has failed a fitness test on his leg and Nick Macleod switches to full back and Lee Thomas returns in the number 10 shirt.
Tom Shanklin and Gethin Jenkins have been retained in the Wales squad preparing to play England so Jonny Bryant partners Tristan Davies in the centre.
In the pack Martin Jones plays at tight-head prop in place of Jenkins and Nathan Budgett packs down alongside new captain Deiniol Jones at lock.
Robert Sidoli is named among the replacements where Nick Walne also returns to action.
Team: Nick Macleod; Dean Dewdney, Tristan Davies, Jon Bryant, Jonny Vaughton; Lee Thomas, Ryan Powell; John Yapp, Rhys Thomas, Martin Jones, Deiniol Jones (captain), Nathan Budgett, Nathan Thomas, Kort Schubert, Robin Sowden-Taylor
Replacements: Ben Evans, Gareth Williams, Robert Sidoli, Maama Molitika, Nick Robinson, Nick Walne, Shaun James
Referee: Alan Lewis (Ireland)