Andrew Lewis returns at hooker and Heino Senekal packs down in the second row.
Craig Quinnell is unavailable as he has an automatic one-match suspension for receiving three yellow cards in this season's Celtic League matches.
Rob Appleyard will undergo knee surgery on Wednesday and will not play again this season. Neither will lock Andy Moore because of a neck injury.
Other players unfit for selection were Donavan van Vuuren (flu), Jonny Vaughton (hamstring), Nick Walne (back), Andrew Moore (hamstring) and Darren Crompton (neck).
Blues' team: Rhys Williams; Tom Shanklin, Jamie Robinson, Iestyn Harris, Craig Morgan; Nick Robinson, Ryan Powell; John Yapp, Andrew Lewis, Ben Evans, Heino Senekal, Jim Brownrigg, Dan Baugh, Nathan Thomas, Martyn Williams (captain)
Replacements: Ken Fourie, Rhys Thomas, James Goode, Robin Sowden-Taylor, Dean Dewdney, Nick Macleod, Matt Allen
Referee: Iain Ramage (Scotland)