The Cardiff Blues travel to the RDS in Dublin to face the Heineken Cup champions Leinster with 10 players missing.
Gareth Cooper, Leigh Halfpenny, Tom James, Jamie Roberts, Tom Shanklin, Bradley Davies, Gethin Jenkins, Andy Powell, Martyn Williams and Sam Warburton have all been called up to the Wales Squad for Invesco Perpetual Series.
Despite recording a 20 point to 12 win over the Ospreys last weekend the Blues know it will be a big challenge out in Dublin, having not won an away fixture so far this season and Leinster unbeaten in their last four matches with Cardiff Blues.
Leinster's four game winning run in the Magners League came to a halt with the 14-16 reversal at Ulster on Friday while the Blues have won two of their last three matches in the Magners League.
With hookers T Rhys Thomas and Gareth Williams and Number 7 Robin Sowden Taylor out injured, young hooker Rhys Williams makes his first start for the Blues, while Ben White also makes his first start of the season at Openside Flanker.
15 Ben Blair 14 Richard Mustoe 13 Gareth Thomas 12 Gavin Evans 11 Chris Czekaj 10 Sam Norton Knight 9 Richie Rees
1 Darren Morris 2 Rhys Williams 3 Taufa'ao Filise 4 Deiniol Jones 5 Paul Tito (C) 6 Scott Morgan 7 Ben White 8 Xavier Rush
16 Rhys James 17 Gary Powell 18 James Down 19 Josh Navidi 20 Darren Allinson 21 Ceri Sweeney 22 Dafydd James
Supporters are urged not to delay and join us for our big Boxing Day fixture with Newport Gwent Dragons in the Guinness PRO12 - with tickets selling fast for the huge game at BT Sport Cardiff Arms Park!
Supporters who have purchased tickets and are travelling to the European Rugby Challenge Cup clash with London Irish at the Madejski Stadium on Saturday (kick-off 3pm) are advised that some seating has now been changed for this fixture.
Supporters are advised that we will selling tickets right up until kick-off for the big home European Rugby Challenge Cup clash with London Irish - so don't miss all the action this Saturday at BT Sport Cardiff Arms Park.
Blues Rugby Camps will be back this February to given children right across our region the opportunity to participate in rugby during the holidays - and you can book NOW to avoid any disappointment and get the ideal Christmas gift for the aspiring young rugby player in your life!