The Cardiff Blues travel to the RDS in Dublin to face the Heineken Cup champions Leinster with 10 players missing.
Gareth Cooper, Leigh Halfpenny, Tom James, Jamie Roberts, Tom Shanklin, Bradley Davies, Gethin Jenkins, Andy Powell, Martyn Williams and Sam Warburton have all been called up to the Wales Squad for Invesco Perpetual Series.
Despite recording a 20 point to 12 win over the Ospreys last weekend the Blues know it will be a big challenge out in Dublin, having not won an away fixture so far this season and Leinster unbeaten in their last four matches with Cardiff Blues.
Leinster's four game winning run in the Magners League came to a halt with the 14-16 reversal at Ulster on Friday while the Blues have won two of their last three matches in the Magners League.
With hookers T Rhys Thomas and Gareth Williams and Number 7 Robin Sowden Taylor out injured, young hooker Rhys Williams makes his first start for the Blues, while Ben White also makes his first start of the season at Openside Flanker.
15 Ben Blair 14 Richard Mustoe 13 Gareth Thomas 12 Gavin Evans 11 Chris Czekaj 10 Sam Norton Knight 9 Richie Rees
1 Darren Morris 2 Rhys Williams 3 Taufa'ao Filise 4 Deiniol Jones 5 Paul Tito (C) 6 Scott Morgan 7 Ben White 8 Xavier Rush
16 Rhys James 17 Gary Powell 18 James Down 19 Josh Navidi 20 Darren Allinson 21 Ceri Sweeney 22 Dafydd James
Cardiff Blues were crowned the Welsh champions of the Premiership Rugby 7s Series on Saturday night to book a place at the Series Final on Friday, August 8 - and you can join them with tickets on sale NOW!
Wales will tonight (Saturday) stage the first leg of the Premiership Rugby 7s Series this Saturday evening at the BT Sport Cardiff Arms Park - and tickets remain on throughout the day and right up until kick-off so you can join us for an summer night of top class rugby!
The Welsh stage of the Premiership Rugby 7s Series explodes into life at BT Sport Cardiff Arms Park this Saturday - and fans attending a night of thrilling regional rugby will also be showing their support for the #StayStrongForOws campaign.
In its sixth year the Blues Cup once again showed to be huge hit throughout the region and is a great advert for the community game as each of the six finalists across the three age groups produced rugby of an outstanding level resulting in 14 tries.
Inspired Cardiff Blues enjoyed Judgement Day at the Millennium Stadium as they secured a tense 17-13 win over regional rivals Scarlets in a feisty and enthralling encounter in the RaboDirect PRO12 on Easter Sunday.