The Cardiff Blues travel to the RDS in Dublin to face the Heineken Cup champions Leinster with 10 players missing.
Gareth Cooper, Leigh Halfpenny, Tom James, Jamie Roberts, Tom Shanklin, Bradley Davies, Gethin Jenkins, Andy Powell, Martyn Williams and Sam Warburton have all been called up to the Wales Squad for Invesco Perpetual Series.
Despite recording a 20 point to 12 win over the Ospreys last weekend the Blues know it will be a big challenge out in Dublin, having not won an away fixture so far this season and Leinster unbeaten in their last four matches with Cardiff Blues.
Leinster's four game winning run in the Magners League came to a halt with the 14-16 reversal at Ulster on Friday while the Blues have won two of their last three matches in the Magners League.
With hookers T Rhys Thomas and Gareth Williams and Number 7 Robin Sowden Taylor out injured, young hooker Rhys Williams makes his first start for the Blues, while Ben White also makes his first start of the season at Openside Flanker.
15 Ben Blair 14 Richard Mustoe 13 Gareth Thomas 12 Gavin Evans 11 Chris Czekaj 10 Sam Norton Knight 9 Richie Rees
1 Darren Morris 2 Rhys Williams 3 Taufa'ao Filise 4 Deiniol Jones 5 Paul Tito (C) 6 Scott Morgan 7 Ben White 8 Xavier Rush
16 Rhys James 17 Gary Powell 18 James Down 19 Josh Navidi 20 Darren Allinson 21 Ceri Sweeney 22 Dafydd James
Cardiff Blues face Newport Gwent Dragons in a huge European Rugby Challenge Cup quarter-final on Saturday, April 4 - and you can celebrate pre and post-match with Cardiff Blues and the Cardiff Blues Supporters' Club at BT Sport Cardiff Arms Park!
Welsh Pro Rugby's main sponsor BT Sport will help make it a Welsh derby day to remember for thousands of rugby supporters at the big European quarter-final with the creation of a buzzing Family Village at Rodney Parade.
Cardiff Blues are hosting a special Open Evening this Wednesday night at BT Sport Cardiff Arms Park to give prospective students and parents the chance to discover more about our new and exciting rugby education programme.
Our Cardiff Blues Rugby Camps return this Easter to give children right across our region the opportunity to participate in rugby during the holidays - and after selling out our last two camps you can book NOW to avoid any disappointment!
Supporters are being invited to get on their bike and gear up for an epic charity bike ride from Cardiff to Paris this June - with the last few places now available to raise vital funds for #StayStrongForOws
The players at Cardiff Blues will be hoping to play with some true Gallic flair for the rest of the Guinness PRO12 season - after the region teamed up with a successful French bistrot in the Welsh capital.
Cardiff Blues will be celebrating St David's Day when the region faces Edinburgh Rugby at BT Sport Cardiff Arms Park on Sunday afternoon (kick-off 12.45pm) - with hundreds of children invited as part of our Regional Schools Day.
Fine footwear retailer The Brogue Trader - one of the official sponsors of Cardiff Blues - is celebrating after being recognised by the British Footwear Association at its annual Footwear Industry Awards.
Battling Cardiff Blues produced a second half performance packed full of character and spirit to push Ulster Rugby all the way in an absorbing Guinness PRO12 encounter at a packed out Kingspan Stadium.
Argentine ace Joaquin Tuculet scored a sensational try in the eighth minute of injury time as Cardiff Blues produced an astonishing finale to snatch victory over Connacht Rugby after an unbelievable Guinness PRO12 encounter.