The Cardiff Blues travel to the RDS in Dublin to face the Heineken Cup champions Leinster with 10 players missing.
Gareth Cooper, Leigh Halfpenny, Tom James, Jamie Roberts, Tom Shanklin, Bradley Davies, Gethin Jenkins, Andy Powell, Martyn Williams and Sam Warburton have all been called up to the Wales Squad for Invesco Perpetual Series.
Despite recording a 20 point to 12 win over the Ospreys last weekend the Blues know it will be a big challenge out in Dublin, having not won an away fixture so far this season and Leinster unbeaten in their last four matches with Cardiff Blues.
Leinster's four game winning run in the Magners League came to a halt with the 14-16 reversal at Ulster on Friday while the Blues have won two of their last three matches in the Magners League.
With hookers T Rhys Thomas and Gareth Williams and Number 7 Robin Sowden Taylor out injured, young hooker Rhys Williams makes his first start for the Blues, while Ben White also makes his first start of the season at Openside Flanker.
15 Ben Blair 14 Richard Mustoe 13 Gareth Thomas 12 Gavin Evans 11 Chris Czekaj 10 Sam Norton Knight 9 Richie Rees
1 Darren Morris 2 Rhys Williams 3 Taufa'ao Filise 4 Deiniol Jones 5 Paul Tito (C) 6 Scott Morgan 7 Ben White 8 Xavier Rush
16 Rhys James 17 Gary Powell 18 James Down 19 Josh Navidi 20 Darren Allinson 21 Ceri Sweeney 22 Dafydd James
Thank Blues it's Friday! The weekend will be starting HERE on Friday night as Cardiff Blues tackle Ulster in the Guinness PRO12 at BT Sport Cardiff Arms Park - and we want you to be our guest at our big match day party!
Let the Games Begin! Cardiff Blues launch the Guinness PRO12 season on home soil this Sunday afternoon against Glasgow Warriors (kick-off 4pm) - and we are going to make it a double celebration as we also recognise the achievements of Team Wales!
First team aces Cory Allen, Lloyd Williams, Ellis Jenkins and new signing Jarrad Hoeata were all on hand to watch the next generation of stars when Cardiff Blues held a huge Under-8s Tag Rugby tournament at BT Sport Cardiff Arms Park.
Second half tries from Dan Tuohy and Ian Humphreys saw Ulster claim the Friday night points on offer as Cardiff Blues suffered a 26-9 defeat to the impressive Irish province at BT Sport Cardiff Arms Park.
Clinical Glasgow Warriors produced a devastating final 20 minutes to secure the points on Super Sunday and consign battling Cardiff Blues to a 33-12 defeat in the Guinness PRO12 opener at BT Sport Cardiff Arms Park.
Impressive Cardiff Blues pushed English powerhouse side Leicester Tigers all the way with an hugely encouraging performance as final preparations for the new Guinness PRO12 season continued at Welford Road.