Norton-Knight made his state debut for the ACT against Fiji in the lead up to the 2003 Rugby World Cup and made his Super Rugby debut in 2005 for the Brumbies and joined the Waratahs in 2006.
Speaking ahead of the match Sam said, "It's good for me to get some game time before the start of the league and obviously important to get a run under my belt. A friendly match is best environment to do it so I'm really looking forward to it."
"It been a bit frustrating not being able to take full part in training and has made things a bit difficult with new patterns to learn and understand the plays fully from the sidelines."
"Not spending time on the pitch means you can't develop as much as you'd like that's why this week has been so good."
"I've certainly been impressed with the attention to detail in the sessions and have played with Gareth and Richie inside me. They both have great service which makes things a bit easier for whoever is playing 10."
The Blues also welcome back John Yapp and Leigh Halfpenny who also missed out on last Friday's match.
Northampton as expected to bring their strongest squad for the match which could prove to be another challenging match for the Blues.
15 Chris Czekaj 14 Richard Mustoe 13 Dafydd James 12 Gareth Thomas 11 Leigh Halfpenny 10 Dai Flanagan 9 Gareth Cooper
8 Xavier Rush 7 Robin Sowden Taylor 6 Andries Pretorius 5 Paul Tito 4 Bradley Davies 3 Gary Powell 2 T Rhys Thomas 1 John Yapp
16 Darren Morris 17 Gareth Williams 18 Scott Morgan 19 Sam Wartburton 20 Maama Molitika 21 Richie Rees 22 Ceri Sweeney 23 Sam Norton Knight 24 Ryan Howells
To purchase tickets call the ticket office on 0845 345 1400 or buy online at www.cardiffblues.com