The only match between two Amlin Challenge Cup teams - Connacht Rugby and Bourgoin - will launch the weekend's matches in Galway on Saturday, 10 April.
And British & Irish Lions outside halves Jonny Wilkinson and Stephen Jones could go head-to-head in the south of France on the Saturday night when Toulon take on the Scarlets at Stade Felix-Mayol.
The all-England match between London Wasps and Gloucester Rugby will be the first up on Sunday before quarter-final No 4 at Kingston Park Stadium.
AMLIN CHALLENGE CUP QUARTER-FINALS
(All kick-offs local time)
SATURDAY 10 APRIL
13.00 Connacht v Bourgoin - Eurosport
21.00 Toulon v Scarlets - FR4
SUNDAY 11 APRIL
14.00 London Wasps v Gloucester Rugby - Sky Sports
15.00 Newcastle Falcons v Cardiff Blues