Blues prop Gethin Jenkins has withdrawn from the Wales starting line up for the RBS 6 Nations clash with England at Twickenham on Saturday after failing a fitness test this afternoon (Thursday) on a calf problem picked up in training.
Jenkins will be replaced in the starting line-up by prop Paul James and the uncapped Rhondda-born Saracens propand former Cardiff Blue Rhys Gill takes up the spot vacated by James on the bench.
"Paul James has been one of the form props in the Welsh regions so far this season and we are confident he will be a more than able
deputy for Gethin," said Wales head coach Warren Gatland.
"Obviously it's not ideal for us to lose Gethin at this stage and we wish him a speedy recovery."
Jenkins will remain in the Wales camp and his injury will be re-assessed next week.
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Impressive Cardiff Blues pushed English powerhouse side Leicester Tigers all the way with an hugely encouraging performance as final preparations for the new Guinness PRO12 season continued at Welford Road.