Sale Sharks are currently second in the group behind leaders Toulouse, while the Blues will aim to overtake them if they win the crunch match.
Speaking ahead of the match Cardiff Blues Director of Rugby, David Young said.
"This is a huge match for the region as we aim to reach the quarter finals for the third consecutive year."
"We were bitterly disappointed to lose up in Sale in October, when a few harsh decisions cost us the match, but we will be looking to make up for it with a big performance against the Sharks on Saturday."
"Hopefully a big crowd will turn up to get behind the players. The fans have been superb all season and we're urging them to help lift the players in what is a make or break match for us."
Tickets for the match are on sale now with under 16's being able to watch the crucial match from only £5. Family tickets (2 adults and 2 children) are available costing just £40 in the Family Stand.
Reserved seating tickets are priced at only £25 while unreserved seating tickets cost just £20.
Match day tickets are priced as follows:
Premium Seats - Grandstand Blocks W4 W5 W6 Adults - £30 No junior concession
Reserved Seating - Ninian and Grandstand Adults £25 Juniors £10
Unreserved Seating - Ninian Stand
Adults - £20
Juniors - £10
Family Stand - Grandstand Blocks W1
To purchase tickets call the ticket office on 0845 345 1400 or buy online at www.cardiffblues.com/tickets