The introduction of the two new Italian franchises will take the number of teams in the Magners League back up to 12 for the first time since the 2003/04 season, when Welsh rugby moved to a regional system.
Grand Final runners-up Leinster travel to another of the Play-Off sides last season, Glasgow Warriors, on the opening weekend, but then host Cardiff Blues at the RDS in Round 2.
The increase in numbers means there will be four extra rounds of matches in the league phase of the tournament. In order to accommodate this some games are scheduled to be played during the International windows in November and while the RBS 6 Nations championship is being played.
The 22 round league season kicks-off on the first weekend in September 2010 and runs through until the weekend of 6 May 2011. All games in Round 22 will kick-off simultaneously to ensure that no teams have advantage when vying for Play-Off places or European qualification.
The top four teams in the regular season will once again progress to the Play-Off semi finals, which will be held on the weekend of 13 May. The Magners League Grand Final will be played on the weekend of 27 May, 2011.
At this stage the fixtures are weekend only dates. Specific dates, kick-off times and in some cases, venues, will be released after consultation with the individual teams and the Magners League broadcast partners.
All regular season Magners League matches are included in the 2010/11 Cardiff Blues Season Ticket package, which also includes access to all Heineken Cup pool matches and all Anglo-Welsh Cup pool matches.
All fixtures are subject to change
Sept 4th Edinburgh h TBD ML1
Sept 11th Leinster a TBD ML2
Sept 18th Dragons h TBD ML3
Sept 25th Ben. Treviso a TBD ML4
Oct 2nd Connacht h TBD ML5
Oct 23rd Scarlets h TBD ML6
Oct 30th Airioni Rugby a TBD ML7
Nov 20th Ulster h TBD ML8
Nov 27th Glasgow h TBD ML9
Dec 4th Munster a TBD ML10
Dec 25th Dragons a TBD ML11
Jan 1st Ospreys h TBD ML12
Jan 8th Airioni Rugby h TBD ML13
Feb 12th Glasgow a TBD ML14
Feb 19th Leinster h TBD ML15
Feb 26th Ulster a TBD ML16
March 5th Edinburgh a TBD ML17
Mar 26th Munster h TBD ML18
April 2nd Ospreys a TBD ML19
April 16th Connacht a TBD ML20
April 23rd Ben. Treviso h TBD ML21
May 7th Scarlets a TBD ML22
May 14th ML SEMI FINALS TBD ML
May 28th ML FINAL TBD ML