Edinburgh have become something of a bogey team for the Blues in recent seasons, but after becoming the first Welsh region to lift European silverware last season, Cardiff Blues will be keen to continue and improve upon their success this term.
The week after Edinburgh visit, the Blues travel to the south of France to meet Castres Olympique at the Stade Pierre Antoine, on Friday 15th October ko 9.00pm (local time).
The Blues now have a habit of performing well on the road in Europe and have strengthened their squad over the summer with players such as Dan Parks and Michael Paterson joining from Glasgow and Crusaders respectively.
The pre-Christmas back to back matches of rounds 3 & 4 will pit Cardiff Blues against the team that lifted the European Challenge Cup the season before them, Northampton Saints.
The Saints are an increasingly formidable force, following some memorable clashes against Munster last season and in English Premiership they reached the semi-final of last year's competition, only to be beaten at home by Saracens.
This season they welcome the Blues to Franklin's Gardens on Saturday 11th December, kick off 5.45pm.
The following weekend Northampton, will travel down to Cardiff to face the Blues on Sunday 19th December, kick off 3.00pm.
After the Christmas break the Blues host Castres on the weekend of 14/15/16 January and round 6, when the Blues will travel to Edinburgh will be played over the weekend of 21/22/23 January, the dates and times of these matches will be confirmed after round 4.
Fri Oct 8 Northampton Saints v Castres Olympique KO17.45 Franklin's Gardens
Sat Oct 9 Cardiff Blues v Edinburgh Rugby KO17:45 Cardiff City Stadium
Sat Oct 16 Edinburgh Rugby V Northampton Saints KO13.35 Murrayfield
Fri Oct 15 Castres Olympique V Cardiff Blues KO21.00 Stade Pierre Antoine
Sat Dec 11 Northampton Saints V Cardiff Blues KO17.45 Franklin's Gardens
Sat Dec 11 Castres Olympique V Edinburgh Rugby KO19.00 Stade Pierre Antoine
Sun Dec 19 Cardiff Blues V Northampton Saints KO15:00 Cardiff City Stadium
Sun Dec 19 Edinburgh Rugby v Castres Olympique KO14:00 Murrayfield Stadium
Round 5: 14/15/16 January 2011
Northampton Saints v Edinburgh Rugby KO TBD Franklin's Gardens
Cardiff Blues v Castres Olympique KO TBD Cardiff City Stadium
Round 6: 21/22/23 January 2011
Edinburgh Rugby v Cardiff Blues KO TBD Murrayfield
Castres Olympique v Northampton Saints KO TBD Stade Pierre Antoine