When the sides met at Rumney RFC back in October, the South came out on top 17-14. A similar result would certainly stand them in good stead, although the Dragons do have a game in hand as the competition reaches its final straight.
The other game sees the Blues North, who are fourth with eight points from six games, take on the Scarlets who are rock bottom with only three points from their half dozen matches.
It was 14-12 to the North when the sides met at Stradey Park five months ago.
Dragons v Blues South (at Bedwas RFC)
Blues South Team: James Loxton, Nick Gill, Michael Bendon, Will Rees, Joe Xiberras, Joe Deacon, Tom Marley, Daniel Holliday, Carl Fish, Kyle Halley, Owen Sedgebeer, Ryan Moore, Liam Usman, Cory Hearne (c), Rhys Meredith
Luke O'Brien, Adam Thompson, Ollie Morris, Tom Meatyard, Lloyd Williams, Luke Fear, Freddie Wilson
Blues North v Scarlets (at Ynysybwl RFC) - Match postponed