Craig Morgan switches from full back to wing, while Gareth Williams and Ben Evans return to the front row and Robin Sowden-Taylor plays at flanker.
Craig Quinnell has a torn hamstring so Jim Brownrigg starts at lock. Matt Allen has influenza.
Not available for selection are Dean Dewdney, Richard Smith and Rhys Thomas, all long-term injuries, plus Andrew Lewis (head injury), Nick Macleod (knee), James Malpas (shoulder), Pieter Muller (ankle), Jonny Vaughton (hip), Darren Crompton, Allen and Quinnell.
Four others - Iestyn Harris, Tom Shanklin, Martyn Williams and Rhys Williams - are on Rugby World Cup duty with Wales.
Heino Senekal returns from Namibia this week.
Team: Donavan van Vuuren; Lee Abdul, Nick Walne, Jamie Robinson, Craig Morgan; Nick Robinson, Ryan Powell; Kenneth Fourie, Gareth Williams, Ben Evans, Jim Brownrigg, Andy Moore (captain), Rob Appleyard, Nathan Thomas, Robin Sowden-Taylor
Replacements: John Yapp, Leyton Phillips, Dan McShane, Dan Baugh, Andrew Moore, Gareth McCarthy,Richard Jones
Referee: Gregg Davies (Scotland)