The Blues have a first-round bye in the Celtic Cup this weekend but several of their players will test their match fitness with the Premier Division side.
As well as Powell, number 8 Nathan Thomas starts against Bridgend after two weeks on the Blues' replacement bench.
Also in this evening's team are Richard Jones, Robin Sowden-Taylor, Chris Stamatakis and Ryan Price, further emphasising the interaction between the semi-professional club team and the regional squad flying the flag in the Celtic League and Cup.
Prop Darren Crompton who has missed the start of the season with a shoulder injury is expected to play for Cardiff against Llandovery at the Arms Park on Saturday (kick-off 2.30pm) ahead of the Blues next Celtic League fixture against The Borders at Galashiels on 26 September.
Cardiff RFC lost 26-35 to Bridgend RFC.
Elgan Jones; Jamie Henthorn, Richard Jones, Gareth Bowen, Francesco Brillante; Gareth McCarthy, Ryan Powell; Rob Benson, Ryan Price, Darren Fenton, Gareth Knight, Chris Stamatakis, Nick Hampson, Nathan Thomas, Robin Sowden-Taylor
Replacements: Lewis Collins, Ross Davies, Alex Luff, Peter de Snyder, Owen Ruttley, Chris John, Leon Andrews