Into the side come Ben Evans at tight-head prop, Dan McShane at lock and Rob Appleyard and James Malpas in the back row. The positional changes see Ken Fourie move across to loose-head prop and Dan Baugh switched to open-side flanker.
Additions to the Blues' injury list include hooker T Rhys Thomas, who will be sidelined for up to four months with a torn cartilage, and Jim Brownrigg, who was stretchered off in Glasgow but expects to be available again in a fortnight.
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Blues team: Donavan van Vuuren; Nick Walne, Jamie Robinson, Nick Macleod, Dean Dewdney; Nick Robinson, Andrew Moore; Ken Fourie, Andrew Lewis (capt), Ben Evans, Dan McShane, Andy Moore, Rob Appleyard, James Malpas, Dan Baugh
Replacements: John Yapp, Ryan Price, Chris Stamatakis, Nathan Thomas, Robin Sowden-Taylor, Richard Jones, Lee Abdul
Connacht team: Mark McHugh, Conor McPhillips, Darren Yapp, Tim Allnutt (capt.), Wayne Munn, Eric Elwood, Chris Keane, Warren O¹Kelly, Bernard Jackman, Adrian Clarke, Damian Browne, Andrew Farley, Michael Swift, John O¹Sullivan, Matt Lacey.
Replacements: John Fogarty, Fabian Boiroux, Mike McCarthy, Mick Carroll, Conor O¹Loughlin, David Hewitt, Ted Robinson,
Referee: Rob Dickson (Scotland)