Andrew Moore comes in at scrum half while in the pack Heino Senekal teams up with Andy Moore in the second row and Jim Brownrigg plays as a flanker.
Among the replacements hooker Rhys Thomas is set to play his first game since late-August.
Team: Nick Robinson; Rhys Williams, Tom Shanklin, Matt Allen, Craig Morgan; Iestyn Harris, Andrew Moore; John Yapp, Gareth Williams, Darren Crompton, Heino Senekal, Andy Moore, Jim Brownrigg, Nathan Thomas, Martyn Williams, capt
Replacements: Kenneth Fourie, Ben Evans, Rhys Thomas, Craig Quinnell, Dan McShane, Ryan Powell, Nick Walne
Referee: Nigel H Williams (Bryncoch)