Blues and Pontypridd wing Owen Jenkins will make his Wales Under 20 debut when he starts on the right wing. Jenkins, son of former Wales hooker Garin, has impressed for the Principality Premiership champions at the business end of the season and was added to Wales' Junior World Championship squad following injury and call-ups to the senior Wales squad.
In addition, there are three more changes to the starting line-up that faced England in the final game of the Under 20 Six Nations in March, including Blues Ethan Lewis who starts in the front row in place of Elliot Dee.
Wilson said, "Team selection is based around performance during training over the past month or so and also in the knowledge that we want to give players a chance to impress in this competition with five games coming up in 19 days. While we have three new players to the starting line-up, the rest of the side have a lot of experience from the Six Nations.
"We are going into the Samoa game quite blind about the opposition. We have seen the players around the hotel and they seem very big and physical as you would expect. We face them at their most dangerous in the opening game of the tournament, they will be at their freshest and it will require a good performance from us to win. Having said that, we have settled in well, we have completed a good period of training and now we just need to get that first game underway."
Wales Under 20 team v Samoa, Wednesday 5 June, Nantes (6pm local time):
Hallam Amos (Dragons); Owen Jenkins (Blues / Pontypridd), Steffan Hughes (Scarlets / Llanelli), Jack Dixon (Dragons), Ashley Evans (Ospreys/ Bridgend); Sam Davies (Ospreys / Swansea), Joshua Davies (Dragons / Bedwas); Gareth Thomas (Scarlets / Carmarthen), Ethan Lewis (Blues / Cardiff), Nicky Thomas (Ospreys / Swansea), Carwyn Jones (Scarlets/ Carmarthen), Rhodri Hughes (Ospreys/ Swansea), Ellis Jenkins (capt, Blues / Cardiff), Daniel Thomas (Scarlets / Llanelli), Ieuan Jones (Dragons)
Replacements: Elliot Dee (Dragons / Bedwas), Thomas Davies (Blues /Cardiff), Dan Suter (Ospreys/ Bridgend), Jack Jones (Ospreys / Rovigo), Sion Bennett (Scarlets/ Carmarthen), Rhodri Williams (Scarlets/ Llandovery), Harri Evans (North Wales / RGC 1404), Dion Jones (Scarlets/ Llanelli)